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Meanwhile, emerging metabolic imaging techniques, such as hyperpolarized magnetic resonance imaging (HP-MRI) and photoacoustic imaging, can now track in real-time the pyruvate/lactate conversion ratio, mitochondrial membrane potential, and dynamic changes in ROS [172]

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[7] There are three major families of superoxide dismutase, depending on the protein fold and the metal cofactor: the Cu/Zn type (which binds both copper and zinc), Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel)