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Alterations in the microbial flora, gut inflammation, increased intestinal barrier permeability (forming a leaky gut), bacterial translocation, and exposure to stressful environments in schizophrenia (144, 152, 156), may trigger innate immunity via TLR4 stimulation

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide

Hypoxia-inducible factors (HIFs) orchestrate adaptive transcriptional programs that enhance glycolysis, angiogenesis, acidosis, and survival signaling, while metabolic rewiring toward aerobic glycolysis, glutaminolysis, and lipid metabolism supports rapid proliferation and therapeutic resistance

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0.125 g/ml) for 1 h then co-incubated with inhibitors and nanocarriers for 4 h