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The SAM molecule is a universal methyl donor that is active in the methylation of many acceptor compounds, such as DNA, RNA, proteins, creatine, and phospholipid membranes

Recurrent intrahepatic cholestasis Recurrent intrahepatic cholestasis (RIC), historically also known as BRIC (benign recurrent intrahepatic cholestasis), is a disorder characterized by high levels of bilirubin and ALP, a minimum of two episodes of jaundice, and normal or nearly normal values for GT