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Exceeded expectations

Nausea occurred in approximately 24-33% of participants across all tirzepatide doses, but it was most common during dose escalation phases and typically resolved within two to three weeks of stabilizing at a new dose

That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route