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Current FDA labeling for semaglutide products includes warnings or precautions involving: Acute pancreatitis Acute gallbladder disease Acute kidney injury due to volume depletion Severe gastrointestinal reactions Hypoglycemia when combined with insulin or insulin secretagogues Diabetic retinopathy complications in susceptible patients Serious hypersensitivity reactions Pulmonary aspiration risk during general anesthesia or deep sedation Semaglutide labeling also contains a boxed warning regarding thyroid C-cell tumors observed in rodents

13 In the PIONEER-6 study, which compared oral semaglutide to placebo, retinopathy or adverse events related to DR occurred in 7.1% of semaglutide and 6.3% of placebo subjects

Not everyone will have this side effect, but for some, the interplay between hormonal balance and body weight shifts can be a factor that contributes to period irregularity

In our experience, the majority of our patients maintain their weight loss results several months or years following semaglutide discontinuation

Different licensed pharmacies may compound medications at different concentrations while delivering the same prescribed dose