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In a rat model with alternating mania- and depression-like behaviors, viral D1 overexpression in glutamatergic neurons in the medial PFC (mPFC) resulted in mania-like behavior, and termination of viral D1 overexpression alone was sufficient to induce depression-like behavior (Sonntag et al., 2014

Conclusions and perspectives A major challenge of developing vaccines against variable viruses, such as coronaviruses, is the difficulty in inducing immunity that cross-recognizes and protects against the full spectrum of possible viral variants while also limiting the opportunity for immune escape

Acta physiologica Pharmacol

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