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Because it is non-pyrogenic, it does not contain fever-inducing substances (pyrogens), which is a baseline requirement for high-level research integrity

1998 Nov 20;854:27-42

Patients with migraines often need specialized care from neurology-trained providers to evidence-based treatments like medications, neuromodulation devices, or lifestyle management strategies

Possible changes in plasma levels of hepatically metabolized drugs Need for monitoring when used with narrow therapeutic index agents Concomitant administration with antioxidants and vitamin supplements is generally well tolerated, though excessive antioxidant load may blunt physiological redox signaling

At this point, the compounds are generally non-toxic and excreted from the body through bile or urine