In its guidelines, the AAP says doctors need to weigh the medications' "indications, risks, and benefits." Among all medications used for weight loss, the most commonly reported side effects are nausea and constipation, but irreversible gallbladder and pancreatic disease are also reported
In septic mice, semaglutide attenuated sickness behavior, hypothermia, systemic inflammation, and lung injury through the downregulation of pro-inflammatory cytokines (TNF- , IL-1, IL-6, CXCL1), suppression of neutrophil infiltration, and decreased expression of genes associated with tissue remodeling and inflammation (Mmp9, Timp1, Ly6g)
Resources such as Diabetes in Control articles and Healthcare.pro can further support informed discussions between clinicians and patients
doi:10.1093/advances/nmy057 de Ligny W, Smits RM, Mackenzie-Proctor R, et al
They bind to receptors found in multiple organs, including the pancreas, brain, stomach, and cardiovascular system