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It also reduces dark eumelanin in favor of the lighter phaeomelanin

As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)

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2016), a generalization of ANCOVA that allows for missing pretreatment data, executed via nlme 3.1 in R 4.4.2, with unstructured covariance matrices and restricted maximum likelihood estimation

I will try to use it as much as I can afford it