GLP-1 can improve abnormalities in glucose metabolism and excessive lipid accumulation by modulating the activity of FOXO1.5,514 Sirt1, a protein deacetylase, plays a key role in delaying cellular aging and regulating metabolism.515,516,517 GLP-1 may improve the livers antioxidant capacity and metabolic function by activating Sirt1, thereby helping to alleviate the pathological changes associated with NASH
In silico study Comparative in-silico pharmacokinetic (ADMET/PK) and safety profiles This analysis contextualizes the physicochemical differences between -carotene (BC) and doxorubicin (DOX) within the formulation lipid phosphatidylcholine (PC) using computational ADMET predictions
Additionally, we have identified critical knowledge gaps that require future research, including the definition of long-term therapy outcomes, understanding impacts on development and psychosocial well-being, and determining optimal combination therapies
Based on the data of Table 4, in the Intervention group, ginger honey had the most significant effect on increasing estrogen level hormone by 22.754ng/ml (p=0.001)
