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This genetic heterogeneity explains why some patients benefit substantially while others experience limited response

However, even with biochemically optimized thyroid function, many patients continue to experience difficulty with weight management

Some users report improved sleep, energy, or general well-being within weeks

Once the amino acid structure converts to methionine sulfoxide, no amount of refrigeration afterward restores therapeutic function

Also, we enforced the meta-regression to differentiate the confounders and linear relations among the effect size and duration of intervention, and intervention dosage (Reference Mitchell46)