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We found that the glycolytic flux into the TCA cycle was reduced in Gclc fl/fl Mb1-Cre + FoB compared to Gclc fl/fl FoB, as indicated by increased M3-lactate and reduced M2-citrate (Supplementary Fig

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The metabolites detected were acetaminophenglutathione and acetaminophencysteine with their pseudomolecular ions ([M + H] + ) at m / z 457 and m / z 271

Blood was centrifuged in a standard centrifuge (Labofuge 300, Heraeus Holding, Germany) at 3000 g 10 min

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