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The 2003 ESHRE/ASRM-sponsored Rotterdam consensus established the diagnostic framework for PCOS based on combinations of oligo-ovulation, hyperandrogenism, and polycystic ovarian morphology

The results from Evans blue extraction indicated a significant increase in the amount of Evans blue dye that had permeated to both hemispheres, cerebellum and brain stem, through the BBB ( P 0.05, right panel) (Figure 5A)

In patients with renal impairment, which is a very common complication of T2DM, sitagliptin is more suitable than sulfonylureas (100)

IGF1R blockade with ganitumab results in systemic effects on the GHIGF axis in mice

This suggests that metabolic reprogramming may play a pivotal role in the pathogenesis of these skin diseases