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10.1038/s42255-019-0161-5 92 KavyaniB.LidburyB

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Subcutaneous administration works for some peptides but produces inconsistent tissue concentrations for others

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization