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Inhibition of the cAMP-degrading enzyme phosphodiesterase 4 (PDE4) enhances and sustains these cAMP responses, and disruption of G s or cAMP signalling in AP Glp1r neurons abolishes semaglutide-induced weight loss and downstream brain-wide activation

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By binding to GLP-1 receptors in the pancreas, Semaglutide stimulates insulin secretion in response to elevated blood glucose levels while inhibiting the release of glucagon