Additionally, asymmetric dimethylarginine (ADMA), an endogenous inhibitor of eNOS, competes with L-arginine for binding, reducing NO synthesis ( 2+ channels in VSMCs (Smith et al., 2020), triggering depolarizing Ca 2+ spikes in VSMCs leading to vasoconstriction (Ng et al., 2024)
More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27
Glutathione still works as long as timing is managed properly
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