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These results align with a broader analysis of GLP-1RAs as a therapeutic class: a meta-analysis encompassing 52 RCTs by Ren et al., found that GLP-1RA treatment significantly reduced circulating levels of CRP, tumor necrosis factor-alpha (TNF-), interleukin 6 (IL-6), IL-1, and leptin, while increasing adiponectin a hormone associated with anti-inflammatory and insulin-sensitizing properties [112]