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To evaluate the prospect of using collateral sensitivity drugs in the treatment of drug resistant cancers, it was of interest to identify non-toxic and clinically approved drugs that can trigger P-gp-dependent collateral sensitivity

[48] Early reports, not widely circulated, of cases of goiter with exophthalmos were published by the Italians Giuseppe Flajani [51] and Antonio Giuseppe Testa, [52] in 1802 and 1810, respectively

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