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Conditional knockout of TGF-RII/Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation

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In a 2013 study by Korenevsky et al., the researchers administered a combination of melatonin and epithalon to female rats exposed to suboptimal environmental factors, such as light pollution, finding that the combined therapy rectified various impairments of the hypothalamic-pituitary-gonadal axis [13]

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