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These trials prioritize patient-centric endpoints (e.g., DAS28 scores and quality-of-life metrics) but face recruitment challenges due to RA heterogeneity and stringent inclusion criteria (54)

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In patients with AS, the expression of miR-345-3p is upregulated while that of miR-2412 is downregulated in seminal EVs, suggesting that these may influence downstream related proteins through regulation of target genes, thereby affecting sperm motility (Taravat et al., 2024)