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Every time you remove the vial from refrigeration to draw a dose, you expose the solution to temperature fluctuation

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2023 Oct 31;43(10):BSR20230374

Neurotoxins are most effective for expression-related lines and muscle tension, including but not limited to: Forehead lines - Smooth horizontal lines caused by raising the eyebrows Frown lines - Soften vertical lines between the brows Crows feet - Reduce fine lines around the eyes Bunny lines - Minimize wrinkles along the nose Eyebrow lift - Create a subtle lift and open the eyes Lip flip - Enhance the upper lip without adding volume Chin dimpling - Smooth a puckered or orange peel chin Jawline slimming (Masseter muscles) - Slim the jaw and relieve teeth grinding or jaw tension DERMAL FILLERS For Volume and Facial Contouring Whether smoothing lines or adding subtle contour, fillers are tailored to your needs delivering natural results that never look overdone

In this article, Abba Kastin and colleagues review the known effects of DSIP and argue that further work is needed before it can be considered functional