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Evidence suggests that diabetes exacerbates the aggregation of -synuclein, a protein that accumulates in the brain in patients with PD, forming Lewy bodies

In addition, -synuclein pathology is linked with bioenergetics dysfunction in PD by inhibiting the expression of SIRT1 and the development of aberrant mitochondrial morphology (Yan et al

It is a progressive condition eventually leading to kidney failure requiring dialysis or kidney transplantation, and is associated with premature death, mostly from heart disease

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To tackle loose skin and isolated fat pockets, Dr