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Some patients find that the side effect profiles differ enough to make switching worthwhile for reasons beyond temperature concerns

Aggregated proteins can trigger immune responses that intact proteins do not

Research characterized this as a tirzepatide-B12 adduct a covalent or strong non-covalent interaction product between tirzepatide and B12, detected by MS and confirmed by 1D and 2D NMR

One limitation regarding this study was that it involved participants with early stages of PD, so while the data suggest that lixisenatide can delay disease progression, the applications are limited to patients in the early stages

The nausea pattern with sublingual dosing tends to be milder but more frequent than with injections