[21] Within cells, cyanocobalamin is converted to methylcobalamin and 5- deoxyadenosylcobalamin, coenzymes that participate respectively in homocysteine remethylation to methionine and in the isomerization of methylmalonyl-CoA to succinyl CoA, reactions essential for DNA synthesis, erythropoiesis, and myelin maintenance
Human trials are needed to confirm its safety and effectiveness before widespread clinical use
An oversupply with cobalamin is also possible, for which there are pathological causes, for example
A deficiency in B12 can lead to nerve damage and neurological symptoms like tingling or numbness in the hands and feet
Farin HF, Karthaus WR, Kujala P et al (2014) Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-