Meigs JB, Rutter MK, Sullivan LM, Fox CS, DAgostino RB, Wilson PWF
First, as a branched chain fatty acid, VPA combines with carnitine to form valproylcarnitine, which is excreted in urine [42]
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therefore, it can be used as an effective therapeutic tactic to improve diabetes vascular complications.[ , ] Also, arterial blood pressure,[] insulin resistance,[ , ] impaired glucose tolerance,[] and hypoadiponectinemia[] in individuals with diabetes can be safely improved by ALC.[] In this study, we aimed to summarize the results of previous studies that examined the effects of L-carnitine supplementation on lipid profiles, indicators of glycemic control and oxidative stress, and anthropometric indices, to assess the potential relationship between L-carnitine supplementation and metabolic status in individuals with diabetes
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