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It increases the risk for multiple metabolic complications including type 2 diabetes (T2D), metabolic-dysfunction associated steatotic liver disease (MASLD, previously known as non-alcoholic fatty liver disease), cardiovascular disease as well as many mechanical complications such as osteoarthritis and obstructive sleep apnoea (OSA) [3]

Polyphyllin II has been shown to effectively inhibit microvessel growth to suppress vascular formation in an ovarian cancer mouse model, furthermore, polyphyllin II can promote the proliferation of fibroblasts

Semaglutide is marketed under the brand names Ozempic (primarily for diabetes) and Wegovy (for weight loss)

1A for a schematic overview of the differentiation)

GLP-1s, on the other hand, tend to produce greater weight loss and more consistent improvements in insulin resistance