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Furthermore, CatG participates in complex inflammatory response regulation processes, including cytokine, chemokine, and growth factor processing and activation, as well as apoptosis induction through protease three pathways ( In pathological states such as bronchiectasis and COPD, NSP activity in sputum and bronchoalveolar lavage fluid increases markedly, with activity levels correlating positively with disease severity, acute exacerbation risk, and lung function decline rates ( 2.3 Role of DPP1 in NSP activation DPP1 plays an essential role in activating NSP precursor proteins during neutrophil maturation

Cyclin D1 is a key protein in cell proliferation and initiates DNA synthesis (Kang et al., 2018)

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