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Once ipamorelin binds to GHSR-1a, it activates G-protein-coupled receptor signaling that triggers calcium influx and cyclic signaling pathways associated with GH vesicle exocytosis

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MDH (EC 1.1.1.37) activity was measured by monitoring the increase in absorbance at 340 nm ( 340 = 6.2 mmol 1 cm 1 ) and 25 C due to NADH production according to the methods described by Glatthaar et al

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doi:10.1016/s0022-3476(88)80114-8