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If using cooling elements, ensure there is a barrier (such as fabric) between the ice pack and the medication pen

True fat regain follows a predictable timeline based on discontinuation studies: 15-20% weight regain in months 1-3, another 20-30% in months 4-9, plateauing around 70-80% total regain by 12-18 months

For patients with obesity-related comorbidities such as type 2 diabetes or hypertension, optimising management of these conditions may indirectly support weight management

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The multiple sclerosis gut microbiota: a systematic review