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However, how these cellular changes translate to mood effects in individual humans depends on genetic variations, baseline neurotransmitter function, and the person's unique peptide-signaling landscape

The slower erosion curve for biologics (20-30% biosimilar market share after two years, versus 80-90% for small molecules) means that even after formal loss of exclusivity, the price compression that Cost Plus needs to add a drug to its formulary at a meaningful patient savings may not materialize for three to four years post-LOE

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BCS Biowaivers: similarities and differences among EMA, FDA, and WHO requirements

Journal of Biological Chemistry 278 , 3508635092, doi: 10.1074/jbc.M303813200 (2003)