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It is proposed that Ex-4 acts to counteract potassium outflow, thereby delaying repolarization and increasing Ca 2 influx, which in turn enhances insulin secretion [27]

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Huby T, Gautier EL

This can help prevent or relieve constipation and promote overall gut regularity

People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE

Chen PY, Li S, Koh YC, Wu JC, Yang MJ, Ho CT, et al