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Some evidence suggests this drop may begin around age 45coinciding with the transition into perimenopause
Available from: Liao C, Liang X, Zhang X, Li Y (2023) The effects of GLP-1 receptor agonists on visceral fat and liver ectopic fat in an adult population with or without diabetes and nonalcoholic fatty liver disease: a systematic review and meta-analysis
You might notice improved mood and mental clarity within the first week
Histamine : Causes blood vessel dilation, increased mucus production, and itching Prostaglandins (particularly PGD2) : Contribute to inflammation in airways Leukotrienes : Potent contributors to airway constriction (LTC4, LTD4, LTE4) Cytokines : Signal other immune cells to join the response (IL-4, IL-5, IL-6, IL-13) Tryptase : Promotes inflammation and tissue remodeling This is why blocking just one pathway like antihistamines do often isn't enough
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