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Pfizer's internal efforts to develop weight-loss drugs ran into problems last year, resulting in a trio of discontinued programmes, and it has looked externally to replace them, acquiring Metsera for $10 billion after a bidding war with Novo Nordisk last November

Binds extracellular and exchangeable copper(II) ions with high affinity, facilitating copper delivery into cells and enhancing the action of copper-dependent enzymes necessary for extracellular matrix synthesis and antioxidant defenses 2

CNS brain neurons are mainly fueled by glucose metabolized through OXPHOS

70 nm thin sections were collected on 200-mesh copperpalladium grids