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Used in in vitro research examining MC3R and MC4R binding kinetics, receptor selectivity profiling assays, cAMP reporter assays in MC3R/MC4R-expressing cell models, and competitive displacement experiments characterising binding site characteristics of individual melanocortin receptor subtypes

The CREDENCE trial was the first landmark placebo control trial for an SGLT2 inhibitor where the primary outcome being evaluated were the renal outcomes

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C., Arruda, W., Veiga, R