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Translation from preclinical models is complicated by fundamental differences in taste physiology and GLP-1 signaling pathways between rodents and humans

Data from one of the Lilly clinical trials the FDA reviewed found that patients who took the highest dose of Foundayo as directed for 72 weeks lost an average of 27.3 pounds, or 12.4% of their body weight, compared with 2.2 pounds, or 0.9% of average body weight, for those getting a placebo

This was not merely a cosmetic side effect but a potentially therapeutic benefit, given that obesity underlies much of type 2 diabetes

Important concept: GLP-1 analogues produce glucose dependent insulin release, which significantly reduces the risk of hypoglycemia

Monitor for more serious symptoms that require prompt medical attention