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Published investigations describe temporary injection site irritation, redness, mild swelling, local discomfort, and headache among the most commonly observed findings

Headache, particularly at initiation Mild anxiety or restlessness with some compounds Nasal irritation (intranasal administration) Sleep disturbance if dosed too close to bedtime Rare: Mood changes or emotional lability Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a potent hepatocyte growth factor (HGF) receptor agonist originally developed at Washington State University

The results of Mendelian randomization suggest that increasing UA levels as a treatment strategy is unlikely to benefit patients with PD [99]

Psychiatry 20 , 12191231 (2015)

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