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Endoplasmic reticulum stress and oxidative stress The accumulation of lipotoxic speciesincluding free fatty acids (FFAs), diacylglycerols, phospholipids, and free cholesteroltriggers endoplasmic reticulum (ER) stress, leading to activation of multiple cellular stress pathways

The Institutes mission is to drive foundational, collaborative, risk-taking research that addresses societys most pressing challenges, including cancer, Alzheimer's disease, and agricultural vulnerability