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Researchers found that epithalon significantly inhibited the development of tumors in rats exposed to natural light [7]

This once again highlights the idea that the curves of asymmetry of the funnel plot are not likely attributable to systematic publication bias and tend to be more indicative of actual variation in the studies

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Symptoms such as orthopnoea (breathlessness when lying flat), paroxysmal nocturnal dyspnoea, or ankle oedema suggest cardiac causes