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Les donnes prcliniques documentent des effets sur les tendons (Achille, MCL, rotulien), les muscles, la peau (cicatrisation cutane), les os, les nerfs priphriques, le tractus gastro-intestinal (ulcres, colites) et le tissu cardiaque

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Beyond the issue of overdiagnosis in prodromal or ambiguous cases, polypharmacy remains prevalent even among correctly diagnosed patients

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Nevertheless, there are studies providing evidence for an influence of circulating UA on the pathology and behaviour of animal models of PD independent of any humanising effects on uricase activity