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Non-selectivity means the desired effects cannot be separated from unwanted ones

In addition, tirzepatide affects certain chemicals in the brain which in turn decreases food intake, increases energy expenditure, and prevents ectopic fat deposition (abnormal fat accumulation in body parts that normally contains small amounts of fat)

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Kidney Function and Drug Interactions to Monitor Metformin requires dose adjustment or discontinuation if kidney function declines, typically when eGFR falls below 45 mL/min/1.73m