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In another study evaluating the potential of Pinoresinol-4- O --d-glucopyranoside (Pgu) using the lithium/pilocarpine-induced rat model, seizure induction caused an increase in the levels of malondialdehyde (MDA) a marker of oxidative lipid damageand decreased catalase activity, while also increasing the expression levels of PTGS2, all of which was reversed by Pgu pretreatment, which also mitigated neurodegeneration 47

The glucagon receptor component is expected to provide unique metabolic effects including increased energy expenditure and enhanced hepatic lipid oxidation, which may contribute to the substantial body weight reductions observed in Phase 2 clinical trials

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2a), a result that is consistent with the previous study (Supplementary Note 1) 15

Al-Alys observational study used medical records from 2.4 million people with diabetes seen by the Veterans Health Administration between October 2017 and December 2023