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More serious deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes

The DCA curves demonstrated that screening with the GISE risk nomogram model at thresholds greater than 5% resulted in a high net clinical benefit ( Figure 4B )

That dual action is what has made it one of the most talked-about medications in metabolic health

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