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Nephrotoxicity, ototoxicity, dosing pitfalls, and crucial therapeutic drug monitoring
This medication replicates the effects of naturally occurring metabolic hormones from the gut, pancreas, and nervous system
These include: Personal or family history of medullary thyroid carcinoma Personal history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Active or recent history of pancreatitis Pregnancy or planning to become pregnant Breastfeeding individuals Severe gastrointestinal disease or gastroparesis Patients with any of these conditions are advised against using GLP-1 medications, including compounded semaglutide, due to elevated risks identified in clinical studies
Sep 2020;204(3):557-563
Altered gut microbiota in type 2 diabetes: Just a coincidence
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