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Table 1 Efficacy of DPP-4 inhibitors in the clinical phase III programmes with at least 52 weeks duration as add on therapy to metformin compared to sulfonylureas

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10.1016/j.neubiorev.2022.104896 [DOI] [PubMed] [Google Scholar] Biessels G

Sheer says the link between autoimmune disease and cardiovascular risk is likely driven by multiple overlapping factors, including: Inflammation Steroid medications Reduced physical activity during disease flares Insulin resistance High blood pressure Abnormal cholesterol levels Sleep apnea Kidney disease The main message is that patients with obesity and autoimmune disease are a high-risk and historically understudied group, says Sheer