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The researchers generated CoQ10-deficient HT1080 cells by deleting 4-hydroxybenzoate poly pentenyl transferase (COQ2) that catalyzes the first step in CoQ10 biosynthesis

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J Ethnopharmacol 257:112884 Attia GM, Elmansy RA, Elsaed WM (2019) Neuroprotective effect of nilotinib on pentylenetetrazol-induced epilepsy in adult rat hippocampus: involvement of oxidative stress, autophagy, inflammation, and apoptosis [J]