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Because the article treats animal data as mechanistic rather than predictive

This mechanism explains why patients often see drops in triglyceride levels within weeks of starting therapy, even before significant weight loss occurs

This compares favorably to the safety profile of PDE5 inhibitors where side effects such as headache and flushing occur in over 25% of patients, a rate 2 to 3 times higher than with placebo [46, 47]

Alternative or supplementary options (NAD+ infusions, vitamin C dominant protocols) are sometimes considered in specific cases

The active ingredient, glutathione, is then directly absorbed into the bloodstream through the rich vascular supply of the oral mucosa