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164 In a randomized crossover trial in 50 subjects with male infertility, one month of treatment with a supplement containing pine bark extract plus L-arginine (an amino acid precursor to nitric oxide which regulates blood vessel function) increased semen volume, sperm number and concentration, motility, and vitality, and improved sperm morphology compared with placebo

These data demonstrate that ROS generated in endometriosis is largely responsible for the adverse effect of the endometriotic microenvironment on gamete and embryo quality

Therefore, further trials are necessary to investigate the action of antioxidants on the organism in order to improve the reproductive outcome

The primary ones involve worsened side effects like nausea and a risk of hypoglycemia (low blood glucose levels), especially for those with diabetes

Studies have documented effects on delta wave sleep patterns, from which the peptide derives its name