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Qiangsun Zheng, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Cardiovascular and Smooth Muscle Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Repeat flexible sigmoidoscopy up to 30 cm depth on day 10 demonstrated improved severity of proctocolitis (Figure 3)