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Limited human data exists, mostly anecdotal reports and case observations, and no controlled clinical trials have confirmed direct muscle growth or hypertrophy benefits

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Drink enough fluids: hydration matters, especially with vomiting or diarrhea

As clinical experience expands and evidence continues to evolve including in populations without diabetes GLP-1 receptor agonists are likely to play an increasingly central role in modifying CKD progression and improving long-term outcomes