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Notably, similar to the native GLP-1, binding of SR18 to GLP-1R also induces structural changes in the conserved motifs (Figure 17) in comparison to the inactive (PDB: 6LN2) GLP-1R (Wu et al., 2020), which is crucial for intracellular signaling of GLP-1R

(PubMed) Lo RY, Figueroa KP, Pulst SM, et al

Cardiovascular Benefits GLP-1 has been shown to improve endothelial function, reduce blood pressure, and decrease inflammation

Helps in burning long-chain fatty acids for fuel, promoting fat loss

An increase of free radical production occurs in hyperglycemia of diabetes [139] causing LDL glycation, and glycated LDL is more susceptible to oxidation, one reason for the increased LDL oxidation that occurs in poorly controlled diabetes [140]